Spinal cord development

Across TCGA cell cohorts, RNA activity of the Spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A9, METTL25, and RAB11FIP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC2A9 grouped by Spinal cord development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC2A9 →	+3.159	+0.388	.005	.002	3	3
URINARY_TRACT	METTL25 →	+0.824	+0.400	.003	.009	3	3
LIVER	RAB11FIP4 →	+2.991	+1.550	.007	.006	3	3
LIVER	SLC37A4 →	+0.999	+1.583	.003	<.001	3	3
LARGE_INTESTINE	FAM3A →	-0.628	-0.500	.002	.006	3	3
CNS	BTG2 →	+1.340	+0.369	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC2A9 by Spinal cord development activity — URINARY_TRACT

Explore this box plot interactively →