Spinal cord development

Across TCGA cell cohorts, RNA activity of the Spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf3, SRGAP1, and BCKDK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord development activity versus C4orf3 in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C4orf3 →	+0.968	+0.316	<.001	.006	3	4
BREAST	SRGAP1 →	+0.902	+0.212	.004	.003	3	4
CNS	BCKDK →	+0.400	+0.315	.005	.007	3	4
BLOOD_Leukemia	CRACD →	+1.156	+0.329	.003	.004	3	4
BLOOD_Leukemia	FDX1 →	+0.865	+0.592	<.001	.003	3	4
LARGE_INTESTINE	FAAH2 →	-1.478	-0.401	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021510 vs C4orf3 — SOFT_TISSUE

Explore this scatter interactively →