Translesion synthesis

Across TCGA patient cohorts, RNA activity of the Translesion synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, LIG1, and MCM4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translesion synthesis activity versus TOP2A in LUAD (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+0.621	+0.046	<.001	<.001	3	8
GBM	LIG1 →	+0.499	+0.054	.001	<.001	3	8
LUAD	MCM4 →	+0.833	+0.060	<.001	<.001	3	8
LUAD	MCM5 →	+0.765	+0.062	<.001	<.001	3	8
LUAD	MCM2_S27 →	+0.825	+0.049	<.001	<.001	3	7
LUAD	RRM2 →	+0.837	+0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019985 vs TOP2A — LUAD

Explore this scatter interactively →