Lipid storage

Across TCGA patient cohorts, RNA activity of the Lipid storage pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, RPL10A, and TNS2_S102, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid storage activity versus CLIC2 in GBM (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLIC2 →	+0.642	+0.055	<.001	<.001	3	9
OV	RPL10A →	-0.284	-0.034	<.001	.007	3	8
OV	TNS2_S102 →	+0.825	+0.034	<.001	.005	3	8
BRCA	TNS2_S120 →	+0.551	+0.036	<.001	<.001	3	8
BRCA	RSU1 →	+0.364	+0.037	.003	<.001	3	8
GBM	PRKG1 →	+0.387	+0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019915 vs CLIC2 — GBM

Explore this scatter interactively →