Lipid storage

Across TCGA patient cohorts, RNA activity of the Lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFTN2, TLR8, and CD33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid storage activity versus RFTN2 in GBM (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFTN2 →	-0.791	-0.179	<.001	<.001	3	5
GBM	TLR8 →	+1.162	+0.236	<.001	<.001	3	5
GBM	CD33 →	+0.463	+0.149	<.001	<.001	3	5
GBM	MPP1 →	+0.423	+0.203	<.001	<.001	3	5
GBM	LHFPL2 →	+0.449	+0.189	<.001	<.001	3	5
GBM	CD300C →	+0.568	+0.172	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019915 vs RFTN2 — GBM

Explore this scatter interactively →