Lipid storage

Across TCGA cell cohorts, RNA activity of the Lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP4C, SPINT1, and GGCT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid storage activity versus CHMP4C in OVARY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CHMP4C →	-1.578	-0.821	.001	.001	3	4
OVARY	SPINT1 →	-2.722	-0.766	.002	.003	3	4
LUNG_SCLC	GGCT →	-0.784	-0.964	.003	.006	3	4
BONE	SLTM →	-0.547	-0.354	.002	.003	3	3
BONE	TEDC2 →	-1.563	-0.240	.008	.005	3	3
BONE	PTTG2 →	-0.078	-0.294	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019915 vs CHMP4C — OVARY

Explore this scatter interactively →