Pyrimidine nucleobase biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleobase biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PNPT1, MSH6, and TFB2M, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase biosynthetic process activity versus PNPT1 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PNPT1 →	+0.411	+0.069	<.001	<.001	3	10
LSCC	MSH6 →	+0.649	+0.082	<.001	<.001	3	9
UCEC	TFB2M →	+0.645	+0.099	<.001	<.001	2	9
LSCC	TOP2A →	+0.753	+0.059	<.001	<.001	3	8
UCEC	UBR5 →	+0.256	+0.091	<.001	<.001	3	8
UCEC	UTP25 →	+0.392	+0.073	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019856 vs PNPT1 — UCEC

Explore this scatter interactively →