L-ascorbic acid metabolic process

Across TCGA patient cohorts, RNA activity of the L-ascorbic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTA1, RGN, and ZDHHC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-ascorbic acid metabolic process activity versus GSTA1 in HNSC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GSTA1 →	+2.132	+0.105	<.001	<.001	3	5
CCRCC	RGN →	+0.719	+0.128	<.001	<.001	3	5
LSCC	ZDHHC9 →	+0.357	+0.075	.004	.001	3	5
UCEC	LINC01090 →	+0.628	+0.135	.003	.004	2	5
UCEC	ZSCAN31 →	+0.777	+0.146	<.001	.001	3	4
LUAD	VDAC1P7 →	+0.370	+0.075	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019852 vs GSTA1 — HNSC

Explore this scatter interactively →