One-carbon compound transport

Across TCGA patient cohorts, RNA activity of the One-carbon compound transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMTN, ARG1, and USP11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, One-carbon compound transport activity versus DMTN in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DMTN →	+0.411	+0.049	<.001	.002	3	7
PDAC	ARG1 →	+0.874	+0.044	<.001	<.001	3	7
HNSC	USP11 →	-0.274	-0.071	.002	.002	3	6
PDAC	PNISR_S211 →	-0.751	-0.037	<.001	<.001	3	6
GBM	BPI →	+1.259	+0.049	<.001	<.001	3	6
GBM	MMP8 →	+1.286	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019755 vs DMTN — LSCC

Explore this scatter interactively →