Polyol metabolic process

Across TCGA patient cohorts, RNA activity of the Polyol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC27, DNTTIP2, and UBL7-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol metabolic process activity versus CDC27 in LUAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC27 →	-0.225	-0.096	.004	.001	3	5
LSCC	DNTTIP2 →	-0.467	-0.159	<.001	.003	3	5
GBM	UBL7-AS1 →	-0.284	-0.161	<.001	<.001	3	5
GBM	EIF3D →	-0.237	-0.175	.003	.005	3	5
LSCC	RPL32P18 →	-0.430	-0.170	.002	.006	3	5
LSCC	SNORD15B →	-0.592	-0.162	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019751 vs CDC27 — LUAD

Explore this scatter interactively →