Secondary metabolic process

Across TCGA cell cohorts, RNA activity of the Secondary metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1A1, CBFA2T2, and PPP1R37, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secondary metabolic process activity versus AKR1A1 in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKR1A1 →	+0.856	+0.458	<.001	.001	3	9
KIDNEY	CBFA2T2 →	+1.447	+0.270	.004	.007	3	7
BLOOD_Leukemia	PPP1R37 →	+0.522	+0.241	<.001	.001	3	6
STOMACH	THTPA →	+1.668	+1.365	.001	.004	3	5
BLOOD_Leukemia	PELI2 →	+1.280	+0.308	<.001	.003	3	5
BLOOD_Leukemia	KLHDC2 →	+0.417	+0.306	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019748 vs AKR1A1 — BLOOD_Leukemia

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