Antibacterial humoral response

Across TCGA cell cohorts, RNA activity of the Antibacterial humoral response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-A, and HLA-F, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial humoral response activity versus HLA-B in BONE (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HLA-B →	+4.757	+0.421	.002	.007	3	11
BREAST	HLA-A →	+2.587	+0.929	<.001	<.001	3	11
BREAST	HLA-F →	+3.023	+0.934	<.001	.001	3	8
LUNG_SCLC	PSMB8 →	+2.662	+0.908	<.001	.003	2	8
BLOOD_Leukemia	HLA-C →	+1.736	+0.576	.002	.008	2	7
SKIN	IFIT2 →	+1.850	+0.202	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019731 vs HLA-B — BONE

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