Antimicrobial humoral response

Across TCGA patient cohorts, RNA activity of the Antimicrobial humoral response pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR3B, CXCR1, and VNN3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial humoral response activity versus FCGR3B in LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FCGR3B →	+1.133	+0.160	<.001	.003	3	9
LSCC	CXCR1 →	+0.900	+0.227	<.001	<.001	3	9
LUAD	VNN3 →	+0.687	+0.165	<.001	<.001	3	9
HNSC	S100A12 →	+1.372	+0.173	.001	<.001	3	9
GBM	AQP9 →	+1.476	+0.305	<.001	<.001	3	8
UCEC	ZFP36 →	+1.374	+0.258	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019730 vs FCGR3B — LUAD

Explore this scatter interactively →