Antimicrobial humoral response

Across TCGA pan-cancer cohorts, RNA activity of the Antimicrobial humoral response pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 133 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Antimicrobial humoral response pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and CESC, show the opposite pattern, with higher activity associated with better survival.

HNSC, CESC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.447	0.280	<.001	166	view →
CESC	DFS	Quartile	All	0.935	0.779	.003	84	view →
KIRC	DFS	Median	All	0.528	0.719	<.001	75	view →
SKCM	OS	Median	All	0.459	0.272	<.001	66	view →
LIHC	OS	Median	All	0.854	0.712	<.001	65	view →
LGG	DFS	Median	All	0.311	0.467	<.001	53	view →
MESO	DFS	Median	All	0.465	0.277	.002	41	view →
BRCA	DFS	Quartile	All	0.677	0.453	.002	34	view →
GBM	OS	Median	All	0.287	0.520	.006	30	view →
ACC	DFS	Tertile	All	0.838	0.466	.003	30	view →
THYM	OS	Tertile	All	0.749	0.953	.003	27	view →
STAD	DFS	Quartile	II,III,IV	0.735	0.312	.004	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0019730–HNSC (OS)

Open the HNSC breakdown →