GDP-mannose metabolic process

Across TCGA patient cohorts, RNA activity of the GDP-mannose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCP2, COPB1, and PARP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP-mannose metabolic process activity versus SCP2 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCP2 →	+0.237	+0.078	.003	.002	3	5
UCEC	COPB1 →	+0.149	+0.094	.001	.004	3	5
GBM	PARP4 →	+0.448	+0.038	<.001	<.001	3	5
BRCA	PRPF38A_S209 →	-0.357	-0.029	.003	<.001	3	5
COAD	EIF4G1_S1238 →	+0.367	+0.026	.007	.001	3	4
LUAD	SLC25A20 →	+0.234	+0.041	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019673 vs SCP2 — UCEC

Explore this scatter interactively →