GDP-mannose metabolic process

Across TCGA patient cohorts, RNA activity of the GDP-mannose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPI, SNTB2_S208, and CEP170B_S868, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP-mannose metabolic process activity versus MPI in OV (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MPI →	+0.559	+0.161	<.001	<.001	3	4
UCEC	SNTB2_S208 →	+0.656	+0.066	<.001	<.001	3	3
HNSC	CEP170B_S868 →	+0.878	+0.089	<.001	<.001	3	3
OV	DNAJA1_S335 →	-1.416	-0.256	<.001	<.001	3	3
OV	MAN2C1 →	+0.378	+0.166	<.001	.001	3	3
GBM	PPP3CB →	+0.369	+0.120	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019673 vs MPI — OV

Explore this scatter interactively →