GDP-mannose metabolic process

Across TCGA cell cohorts, RNA activity of the GDP-mannose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, ATP6V0A1, and CBFA2T2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYL9 grouped by GDP-mannose metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MYL9 →	-6.393	-2.084	.004	.001	2	5
LUNG_NSCLC_LUSC	ATP6V0A1 →	+0.746	+0.368	.009	.005	3	3
BREAST	CBFA2T2 →	-0.614	-0.749	.008	.006	3	3
URINARY_TRACT	ASAP2 →	-0.814	-1.743	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DTNA →	-1.215	-0.271	<.001	.002	3	3
LUNG_NSCLC_LUAD	STX5 →	-0.591	-0.409	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYL9 by GDP-mannose metabolic process activity — URINARY_TRACT

Explore this box plot interactively →