GDP-mannose metabolic process

Across TCGA cell cohorts, RNA activity of the GDP-mannose metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNK9, MAX, and NUDT8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNK9 grouped by GDP-mannose metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KCNK9 →	-0.237	-0.171	.004	.002	3	4
CNS	MAX →	-0.453	-0.099	.003	.007	2	5
CNS	NUDT8 →	-0.228	-0.078	.006	.007	2	5
BLOOD_Leukemia	APBA1 →	-0.179	-0.115	.001	.001	3	4
BREAST	BBS5 →	+0.180	+0.088	.001	.002	2	5
LUNG_SCLC	BTK →	-0.306	-0.139	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNK9 by GDP-mannose metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →