GDP-mannose metabolic process

Across TCGA cell cohorts, RNA activity of the GDP-mannose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMDS, SPATA13, and CMTM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP-mannose metabolic process activity versus GMDS in LUNG_SCLC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GMDS →	+1.011	+0.719	.001	.005	3	5
STOMACH	SPATA13 →	+1.250	+0.800	.006	.008	3	5
LUNG_NSCLC_LUAD	CMTM3 →	-1.562	-0.635	.006	.002	3	5
SOFT_TISSUE	CEP170B →	+1.420	+1.186	.002	<.001	2	5
LUNG_NSCLC_LUAD	RASEF →	+1.396	+0.799	.002	.001	3	4
LARGE_INTESTINE	TGM2 →	-3.764	-0.802	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019673 vs GMDS — LUNG_SCLC

Explore this scatter interactively →