Urea metabolic process

Across TCGA patient cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPL46, NHSL2, and BAIAP2L2_S478, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea metabolic process activity versus MRPL46 in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPL46 →	+0.279	+0.056	<.001	<.001	3	6
LSCC	NHSL2 →	-0.270	-0.045	<.001	<.001	3	6
PDAC	BAIAP2L2_S478 →	+0.534	+0.038	.001	.001	3	5
CCRCC	LACTB2 →	+0.444	+0.067	<.001	.001	3	5
CCRCC	CGGBP1 →	-0.170	-0.044	<.001	<.001	3	5
LUAD	CLPX →	+0.251	+0.043	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019627 vs MRPL46 — LUAD

Explore this scatter interactively →