Urea metabolic process

Across TCGA patient cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM3, FCGR3B, and CSF3R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea metabolic process activity versus CEACAM3 in LSCC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEACAM3 →	+0.560	+0.135	<.001	<.001	3	5
LSCC	FCGR3B →	+1.413	+0.175	<.001	<.001	3	5
LSCC	CSF3R →	+0.954	+0.177	<.001	<.001	3	4
HNSC	LTBP2 →	-0.446	-0.147	.008	.007	3	4
LSCC	CXCR1 →	+0.797	+0.129	<.001	<.001	3	4
HNSC	CLEC4E →	+0.691	+0.148	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019627 vs CEACAM3 — LSCC

Explore this scatter interactively →