Urea metabolic process

Across TCGA cell cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASS1, NAGS, and TNFRSF25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASS1 grouped by Urea metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ASS1 →	-0.385	-1.236	<.001	<.001	3	8
BREAST	NAGS →	-0.378	-1.255	<.001	<.001	3	6
STOMACH	TNFRSF25 →	-0.212	-1.186	.005	.003	3	6
BONE	ASL →	-0.271	-1.504	.001	<.001	3	5
BREAST	NR1H4 →	-0.344	-0.954	.001	.002	3	4
PANCREAS	TNFSF11 →	+0.278	+1.662	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASS1 by Urea metabolic process activity — BREAST

Explore this box plot interactively →