Urea metabolic process

Across TCGA cell cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIPK3, ZNF84, and SPRYD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIPK3 grouped by Urea metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HIPK3 →	+0.466	+0.774	.002	.001	3	4
SKIN	ZNF84 →	+0.423	+0.925	.006	<.001	3	4
BLOOD_Leukemia	SPRYD4 →	+0.569	+1.405	.001	.001	3	4
BONE	PRCC →	+0.874	+1.752	.001	.002	3	4
LUNG_SCLC	BCL9 →	+0.914	+1.054	<.001	<.001	3	3
BONE	FAM151B →	+0.925	+1.510	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIPK3 by Urea metabolic process activity — SKIN

Explore this box plot interactively →