Urea metabolic process

Across TCGA cell cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGAP1, GUCA1C, and CACNA2D3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RANGAP1 grouped by Urea metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RANGAP1 →	+0.346	+0.329	.009	.009	3	3
LARGE_INTESTINE	GUCA1C →	-0.147	-0.305	.009	.003	3	3
SKIN	CACNA2D3 →	+0.238	+0.297	<.001	<.001	3	3
SOFT_TISSUE	KSR2 →	+0.177	+0.585	.002	.001	2	4
SOFT_TISSUE	OR11G2 →	+0.286	+0.658	.008	.007	3	3
BLOOD_Leukemia	TTC21B →	+0.258	+0.344	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RANGAP1 by Urea metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →