Urea metabolic process

Across TCGA cell cohorts, RNA activity of the Urea metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASS1, WDR49, and GABRE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea metabolic process activity versus ASS1 in LUNG_SCLC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ASS1 →	+2.002	+0.318	.008	.006	3	5
BLOOD_Lymphoma	WDR49 →	+0.223	+0.332	.007	.002	3	4
BREAST	GABRE →	+3.170	+0.306	<.001	.005	3	4
LUNG_NSCLC_LUAD	TGIF2 →	-0.943	-0.341	<.001	<.001	3	4
PANCREAS	BRWD1 →	+0.766	+0.392	.001	.003	3	4
STOMACH	LRG1 →	+1.931	+0.460	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019627 vs ASS1 — LUNG_SCLC

Explore this scatter interactively →