Short-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Short-chain fatty acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCCB, PRPF38A_S209, and MRTO4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Short-chain fatty acid catabolic process activity versus PCCB in LUAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCCB →	+0.444	+0.070	<.001	<.001	3	6
LUAD	PRPF38A_S209 →	-0.409	-0.049	<.001	<.001	3	6
LSCC	MRTO4 →	-0.362	-0.060	<.001	<.001	3	6
GBM	RBM47 →	+0.447	+0.053	.001	.002	3	6
LUAD	FYCO1 →	+0.324	+0.054	.001	.001	3	5
GBM	THOP1 →	-0.179	-0.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019626 vs PCCB — LUAD

Explore this scatter interactively →