Short-chain fatty acid catabolic process

Across TCGA cell cohorts, RNA activity of the Short-chain fatty acid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNS, CDKN1B, and EFCAB14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNS grouped by Short-chain fatty acid catabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CTNS →	+0.160	+1.826	.009	<.001	3	4
LUNG_SCLC	CDKN1B →	-0.185	-1.431	.001	<.001	3	4
BONE	EFCAB14 →	-0.300	-1.578	.007	.009	2	5
LUNG_SCLC	PRKCSH →	-0.185	-1.530	.004	.001	3	3
OVARY	SLC5A2 →	+0.114	+1.636	.005	<.001	2	4
OVARY	GPBAR1 →	+0.170	+1.121	.006	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNS by Short-chain fatty acid catabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →