Short-chain fatty acid catabolic process

Across TCGA cell cohorts, RNA activity of the Short-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFG, TMEM39B, and B3GNT8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Short-chain fatty acid catabolic process activity versus MAFG in LUNG_NSCLC_LUAD (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAFG →	+1.118	+1.306	.002	.001	3	5
BREAST	TMEM39B →	-0.677	-0.786	.009	.006	2	6
BLOOD_Leukemia	B3GNT8 →	+1.813	+1.221	.003	<.001	3	5
SOFT_TISSUE	RIPOR1 →	-1.396	-1.621	.002	.001	3	5
BREAST	ECH1 →	+0.714	+1.043	.002	<.001	3	5
BREAST	CLN3 →	+0.795	+1.040	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019626 vs MAFG — LUNG_NSCLC_LUAD

Explore this scatter interactively →