Peptidyl-proline hydroxylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGLN3, TMEM91, and LCAT, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline hydroxylation activity versus EGLN3 in MESO (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	EGLN3 →	+1.728	+0.054	<.001	<.001	3	25
MESO	TMEM91 →	+1.027	+0.037	.001	.008	2	21
KIRC	LCAT →	+0.820	+0.041	<.001	<.001	3	20
KIRP	MIR210HG →	+1.167	+0.042	<.001	<.001	3	20
PCPG	INAFM1 →	+0.501	+0.028	<.001	<.001	3	19
THYM	P3H2-AS1 →	+1.068	+0.048	.001	<.001	1	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019511 vs EGLN3 — MESO

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