Triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPG2, ATP5F1B, and PTPN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride catabolic process activity versus HSPG2 in BLOOD_Leukemia (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HSPG2 →	-2.800	-0.238	.001	.008	3	5
URINARY_TRACT	ATP5F1B →	+1.067	+1.883	<.001	.006	3	4
LIVER	PTPN1 →	-0.661	-1.295	<.001	.005	3	4
LARGE_INTESTINE	ACAD10 →	+0.658	+0.606	<.001	.007	3	4
LARGE_INTESTINE	FOXA3 →	+2.029	+0.642	<.001	.007	3	4
LARGE_INTESTINE	CD163L1 →	-1.722	-0.812	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019433 vs HSPG2 — BLOOD_Leukemia

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