Triglyceride biosynthetic process

Across TCGA cell cohorts, RNA activity of the Triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRK1, RAB40B, and MGLL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRK1 grouped by Triglyceride biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRK1 →	-1.116	-1.035	.001	.001	3	5
LARGE_INTESTINE	RAB40B →	-0.871	-0.909	.009	.005	3	4
LIVER	MGLL →	-3.475	-1.667	.001	<.001	3	4
STOMACH	ABCF3 →	-0.567	-1.168	.008	.007	3	4
OESOPHAGUS	MROH1 →	-0.718	-0.919	.006	.005	3	4
UPPER_AERODIGESTIVE_TRACT	LAMP5 →	-0.031	-1.074	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRK1 by Triglyceride biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →