Alditol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Alditol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS10, PI3, and THEMIS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alditol biosynthetic process activity versus INTS10 in OV (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	INTS10 →	-0.630	-0.150	.001	.008	3	6
BRCA	PI3 →	-1.859	-0.089	<.001	.007	3	4
BRCA	THEMIS →	-0.543	-0.080	<.001	.001	3	4
BRCA	TRGV10 →	-0.687	-0.102	.006	.003	3	4
UCEC	KIAA0825 →	-0.609	-0.158	.002	<.001	3	4
BRCA	SLA2 →	-0.723	-0.110	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019401 vs INTS10 — OV

Explore this scatter interactively →