Galactose catabolic process

Across TCGA patient cohorts, RNA activity of the Galactose catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4ENIF1, BAG1, and TSC22D2_S598, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose catabolic process activity versus EIF4ENIF1 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EIF4ENIF1 →	-0.247	-0.050	<.001	.002	3	5
LSCC	BAG1 →	+0.239	+0.046	.003	.003	3	4
LUAD	TSC22D2_S598 →	+0.585	+0.037	.001	.005	3	4
LSCC	CRKL →	-0.239	-0.047	.003	.001	3	4
GBM	GRHPR →	+0.418	+0.089	<.001	<.001	3	4
LSCC	IGFBP2 →	-0.938	-0.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019388 vs EIF4ENIF1 — GBM

Explore this scatter interactively →