Galactose catabolic process

Across TCGA cell cohorts, RNA activity of the Galactose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALK1, GALT, and NUDT15, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose catabolic process activity versus GALK1 in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GALK1 →	+1.706	+0.134	<.001	<.001	3	10
OVARY	GALT →	+0.844	+0.101	<.001	<.001	3	9
LUNG_SCLC	NUDT15 →	-0.986	-0.149	<.001	<.001	3	7
LIVER	ARSL →	+2.675	+0.122	.002	.001	3	7
URINARY_TRACT	B4GAT1 →	+1.089	+0.107	.005	.001	2	8
BLOOD_Lymphoma	FAM174A →	+0.893	+0.099	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019388 vs GALK1 — URINARY_TRACT

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