Galactose catabolic process

Across TCGA cell cohorts, RNA activity of the Galactose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLCE, STT3B, and CCDC71, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose catabolic process activity versus GLCE in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GLCE →	+0.765	+0.843	.001	<.001	3	4
LUNG_NSCLC_LUAD	STT3B →	+0.472	+0.986	.007	.001	1	6
OVARY	CCDC71 →	+0.541	+0.978	.003	<.001	3	4
BLOOD_Lymphoma	RBX1 →	-0.459	-0.676	.007	.008	3	3
BLOOD_Lymphoma	TMEM115 →	+0.523	+0.660	.008	.005	2	4
BLOOD_Lymphoma	SLC30A1 →	+1.425	+0.911	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019388 vs GLCE — LUNG_NSCLC_LUAD

Explore this scatter interactively →