Epoxygenase P450 pathway

Across TCGA patient cohorts, RNA activity of the Epoxygenase P450 pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, OSER1-DT, and MILR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epoxygenase P450 pathway activity versus CYP1B1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYP1B1 →	+1.627	+0.614	<.001	.002	3	4
LSCC	OSER1-DT →	-0.391	-0.238	<.001	.007	3	4
LSCC	MILR1 →	+0.586	+0.274	.002	.009	3	4
PDAC	KIAA1958 →	-0.423	-0.809	<.001	.003	3	4
GBM	SLC14A1 →	+1.094	+0.197	.004	.003	3	3
HNSC	SFRP4 →	+1.629	+0.467	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019373 vs CYP1B1 — BRCA

Explore this scatter interactively →