Lipoxygenase pathway

Across TCGA patient cohorts, RNA activity of the Lipoxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSP1, ALOX5AP, and SNRNP200, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoxygenase pathway activity versus LSP1 in CHOL (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	LSP1 →	+1.624	+0.144	<.001	<.001	3	24
LAML	ALOX5AP →	+1.742	+0.137	<.001	<.001	3	24
PCPG	SNRNP200 →	-0.638	-0.093	<.001	<.001	3	24
LAML	NCF1 →	+2.217	+0.128	<.001	<.001	3	24
LAML	JAML →	+1.960	+0.133	<.001	<.001	3	24
LAML	NCF1C →	+2.073	+0.129	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019372 vs LSP1 — CHOL

Explore this scatter interactively →