Cyclooxygenase pathway

Across TCGA patient cohorts, RNA activity of the Cyclooxygenase pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_T755, PLXDC2, and LMOD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclooxygenase pathway activity versus SYNPO2_T755 in UCEC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2_T755 →	+0.673	+0.072	.004	.003	3	8
GBM	PLXDC2 →	+0.538	+0.153	<.001	<.001	3	8
UCEC	LMOD1 →	+0.675	+0.076	.001	<.001	3	8
GBM	ASPN →	+1.139	+0.106	<.001	<.001	3	7
BRCA	CNN1 →	+0.836	+0.053	<.001	<.001	3	7
GBM	SF3B1 →	-0.214	-0.075	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019371 vs SYNPO2_T755 — UCEC

Explore this scatter interactively →