Leukotriene biosynthetic process

Across TCGA cell cohorts, RNA activity of the Leukotriene biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, AP4M1, and PRDX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTA2 grouped by Leukotriene biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ACTA2 →	-1.980	-1.119	.004	.002	3	4
LUNG_SCLC	AP4M1 →	-0.908	-1.339	.001	.001	3	4
STOMACH	PRDX4 →	+1.198	+1.123	.008	.002	2	5
LUNG_NSCLC_LUSC	NEURL2 →	-0.605	-1.656	.008	.001	3	4
LIVER	SLC23A3 →	-0.980	-1.428	.002	<.001	3	4
OESOPHAGUS	PRPS2 →	-1.033	-1.064	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTA2 by Leukotriene biosynthetic process activity — KIDNEY

Explore this box plot interactively →