Fucose catabolic process

pathway activity — cross-omics
GO:0019317Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Fucose catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L1, HIP1R, and SLC12A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMEPB41L1 →+0.359+0.062.003.00135
GBMHIP1R →+0.584+0.073<.001<.00135
PDACSLC12A2 →+0.591+0.079.002.00634
PDACCALML4 →+0.590+0.069<.001<.00134
LSCCPOF1B →+1.134+0.082<.001<.00134
LUADRAP1GAP2_S558 →+0.858+0.077.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration