N-acetylneuraminate catabolic process

Across TCGA cell cohorts, RNA activity of the N-acetylneuraminate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A1, SMIM1, and PARP11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate catabolic process activity versus SLC16A1 in BLOOD_Myeloma (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC16A1 →	-1.011	-1.483	<.001	<.001	3	3
OVARY	SMIM1 →	-1.632	-0.301	.003	<.001	3	3
CNS	PARP11 →	+0.496	+1.268	.005	.005	3	3
CNS	FAM161B →	+0.673	+1.027	.004	.001	3	3
CNS	FAM76A →	+0.885	+1.375	.001	.002	3	3
KIDNEY	DMKN →	+3.336	+1.996	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019262 vs SLC16A1 — BLOOD_Myeloma

Explore this scatter interactively →