Regulation of vasoconstriction

Across TCGA patient cohorts, RNA activity of the Regulation of vasoconstriction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMSS1, PYGL, and BUD23, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasoconstriction activity versus CMSS1 in BRCA (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMSS1 →	-0.584	-0.031	<.001	<.001	3	8
LUAD	PYGL →	+0.513	+0.064	<.001	<.001	3	7
GBM	BUD23 →	-0.390	-0.049	<.001	<.001	3	7
OV	ELAVL1 →	-0.305	-0.025	<.001	<.001	3	7
UCEC	ESF1_S663 →	-0.560	-0.053	.003	<.001	3	7
OV	HNRNPR →	-0.257	-0.017	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019229 vs CMSS1 — BRCA

Explore this scatter interactively →