Regulation of vasoconstriction

Across TCGA patient cohorts, RNA activity of the Regulation of vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARCL1, RCAN2, and RGCC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasoconstriction activity versus SPARCL1 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARCL1 →	+0.967	+0.612	<.001	<.001	3	6
BRCA	RCAN2 →	+0.625	+0.736	<.001	<.001	3	6
LSCC	RGCC →	+0.669	+1.139	<.001	<.001	3	6
OV	VRK1 →	-0.584	-0.687	<.001	.001	3	5
OV	COX4I2 →	+0.802	+0.656	.002	.009	3	5
BRCA	CEP55 →	-1.082	-0.837	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019229 vs SPARCL1 — BRCA

Explore this scatter interactively →