Regulation of vasoconstriction

Across TCGA cell cohorts, RNA activity of the Regulation of vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, AGPAT4, and HRH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasoconstriction activity versus TRAP1 in SKIN (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRAP1 →	-0.661	-0.284	.008	.005	3	5
SKIN	AGPAT4 →	+1.236	+0.334	<.001	<.001	3	5
BONE	HRH1 →	+2.840	+0.339	<.001	.009	3	5
LIVER	GBP1 →	+2.912	+0.358	.002	.003	2	6
LIVER	TSPAN33 →	-2.496	-0.353	.001	.003	3	5
STOMACH	PLAAT4 →	+2.347	+0.384	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019229 vs TRAP1 — SKIN

Explore this scatter interactively →