Transmission of nerve impulse

Across TCGA cell cohorts, RNA activity of the Transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX2, DDB2, and DOCK10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRPX2 grouped by Transmission of nerve impulse-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SRPX2 →	+2.085	+0.247	.006	.008	3	4
STOMACH	DDB2 →	-0.849	-0.275	.006	<.001	3	4
LUNG_NSCLC_LUAD	DOCK10 →	+1.820	+0.257	.001	<.001	3	4
BONE	MPND →	-0.930	-0.190	.005	.005	3	4
CNS	NRIP3 →	+1.919	+0.187	.001	.009	3	4
BONE	MAP7D3 →	+1.348	+0.226	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRPX2 by Transmission of nerve impulse activity — STOMACH

Explore this box plot interactively →