Regulation of steroid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSTB, GPR182, and GNAO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid metabolic process activity versus CSTB in CNS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CSTB →	+1.180	+0.182	.003	.001	3	6
CNS	GPR182 →	-0.146	-0.230	.003	.001	3	5
UPPER_AERODIGESTIVE_TRACT	GNAO1 →	-2.110	-0.334	.001	<.001	3	5
BREAST	ERLIN2 →	+1.177	+0.235	.004	.003	3	5
LUNG_NSCLC_LUSC	MAPK1 →	+1.389	+0.291	<.001	.003	3	5
LUNG_NSCLC_LUSC	PPIL2 →	+0.876	+0.243	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019218 vs CSTB — CNS

Explore this scatter interactively →