Regulation of fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD14B, PFDN1, and IGSF9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid metabolic process activity versus ABHD14B in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ABHD14B →	+1.032	+0.229	.007	.001	3	6
BONE	PFDN1 →	+0.842	+0.383	.005	.003	3	5
STOMACH	IGSF9 →	-2.742	-0.224	<.001	.009	3	5
OVARY	VTCN1 →	-4.498	-0.377	<.001	<.001	3	5
OVARY	GPATCH1 →	-0.559	-0.196	.003	.005	3	5
LUNG_NSCLC_LUAD	TSPAN15 →	-1.839	-0.289	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019217 vs ABHD14B — LUNG_SCLC

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