Regulation of fatty acid metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of fatty acid metabolic process pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and LIHC, show the opposite pattern, with lower activity in tumor tissue.

KIRP, LIHC, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.050	<.001	9	view →
LIHC	Male	II,III,IV	−0.038	<.001	8	view →
THCA	Female	All	−0.021	<.001	8	view →
KICH	Male	III,IV	−0.047	.002	7	view →
LUAD	All	All	−0.020	<.001	7	view →
BRCA	All	III,IV	−0.068	<.001	6	view →
CHOL	Male	All	−0.094	<.001	3	view →
LUSC	All	All	−0.014	.003	3	view →
READ	Male	All	−0.023	.024	2	view →
KIRC	All	All	−0.008	.020	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0019217–KIRP

Open the KIRP breakdown →