Viral genome replication

Across TCGA cell cohorts, RNA activity of the Viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNNM1, XIAP, and ZCCHC18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral genome replication activity versus CNNM1 in STOMACH (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CNNM1 →	-1.698	-0.250	.006	.002	3	5
LUNG_SCLC	XIAP →	+0.850	+0.225	<.001	<.001	3	5
LUNG_SCLC	ZCCHC18 →	+1.369	+0.128	.003	.007	3	5
LUNG_SCLC	RUFY3 →	+1.796	+0.228	.001	<.001	3	5
BREAST	CTBP1 →	+1.105	+0.234	<.001	<.001	3	5
SKIN	MTA2 →	+0.485	+0.133	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019079 vs CNNM1 — STOMACH

Explore this scatter interactively →