Virion assembly

Across TCGA patient cohorts, RNA activity of the Virion assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, RPL7, and HSP90B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Virion assembly activity versus RPL4 in LUAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL4 →	-0.217	-0.027	.001	<.001	3	5
CCRCC	RPL7 →	-0.203	-0.020	<.001	.004	3	5
LUAD	HSP90B1 →	-0.383	-0.040	<.001	<.001	3	5
GBM	PDIA4 →	-0.280	-0.032	.001	<.001	3	5
LSCC	PPIB →	-0.333	-0.035	<.001	<.001	3	5
LSCC	ELANE →	-0.630	-0.031	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019068 vs RPL4 — LUAD

Explore this scatter interactively →